With a 2.30pm start at Emirates Durham ICG, the Dynamos need to secure a convincing victory to have any chance of reaching the last-16.
Tickets can be purchased on the gate, which opens at 12.30pm, and are priced £20 for adults and £5 for juniors.
Follow the action online via www.durhamccc.co.uk/live-match-chat or follow @DurhamCricket on Twitter.
Durham Dynamos squad to face Lancashire Lightning
Phil Mustard (19)
Herschelle Gibbs (7)
Ben Stokes (38)
Johann Myburgh (4)
Dale Benkenstein (44) Captain
Gordon Muchall (24)
Scott Borthwick (16)
Liam Plunkett (20)
Mitchell Claydon (25)
Chris Rushworth (22)
Graham Onions (9)
Gareth Breese (70)
Will Smith (2)